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KMID : 0381120170390040379
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Genes and Genomics
2017 Volume.39 No. 4 p.379 ~ p.385
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Association of MMP-9 C-1562T polymorphism with risk of Henoch-Schonlein purpura nephritis in children of southeast China
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Xu Jinwen
Zhao Liping
Zhou Hongxia
Ge Tingting
Zhang Lin
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Abstract
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Henoch-Schonlein purpura nephritis (HSPN) is the most prevalent vasculitis in childhood worldwide. Although the etiology of HSPN is not yet fully elucidated, it is believed to be closely related with infections and genetic predispositions. In this study, a cohort of children from southeast China, including 108 healthy controls and 184 patients were involved in. We scanned the promoter region and the whole gene for genetic variations. A C/T transition located in the promoter region of MMP-9 gene, C-1562T was identified. Subjects were genotyped by using SNaPshot sequencing and the frequencies of CC, CT and TT genotypes were 43, 33 and 24% in patients and 53, 37 and 10% in healthy controls. Allele distribution was found to be in Hardy?Weinberg equilibrium (P?=?0.17). Association analysis revealed that the polymorphism was significantly related with HSPN risk (P?
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KEYWORD
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Henoch-Schonlein purpura nephritis, MMP-9, C-1562T polymorphism, Association analysis
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